Endocrine Abstracts

IntroductionHepcidin, main body iron regulator protein, decreases iron concentration available for erythropoiesis. Oppositely, excessive erythropoiesis in acromegaly patients (increased GH and IGF-1), may inhibit hepcidin production. GH stimulates bone marrow, whereas IGF-1 receptors are expressed in erythrocytes. Exogenous GH administration in healthy subjects reduced hepcidin level. The role of hepcidin in iron metabolism of acromegaly patients has not...